The risk for developing brain metastases is higher in patients with more aggressive subtypes of breast cancer, including HER2-positive disease. A retrospective Belgian study identified several risk factors associated with increased risk of brain metastases in these patients, including age younger than 40, tumor size greater than 2 cm, nodal involvement, absence or late start of anti-HER2 treatment, and development of a lung lesion as the first site of relapse. Historically, patients with brain metastases have been excluded from most clinical trials and registration studies, Lin said. Because of this, effective treatment of brain metastases remains an unmet medical need among women with HER2-positive breast cancer. Standard treatment for these patients are local approaches targeted to the brain. Patients with a single metastases would typically undergo surgery, Lin explained.
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Spotting breast cancer's spread to the brain before symptoms start could improve survival
Breast cancer that has spread to the brain 2. Newly diagnosed or worried about a symptom? Treating secondary breast cancer in the brain 5. Managing symptoms of secondary breast cancer in the brain 6.
Breast Cancer Spread to the Brain
In metastasis, cancer cells break away from where they first formed primary cancer , travel through the blood or lymph system, and form new tumors metastatic tumors in other parts of the body. The metastatic tumor is the same type of cancer as the primary tumor. Cancer that spreads from where it started to a distant part of the body is called metastatic cancer. For many types of cancer, it is also called stage IV 4 cancer.
Skip to Content. You will also read general information on surviving the disease. Remember, survival rates depend on several factors. Use the menu to see other pages. A primary brain or spinal cord tumor is a tumor that starts in the brain or spinal cord.