Triple negative is sometimes used as a surrogate term for basal-like ; however, more detailed classification may provide better guidance for treatment and better estimates for prognosis. Triple-negative breast cancers comprise a very heterogeneous group of cancers. There is conflicting information over prognosis for the various subtypes, but it appears that the Nottingham prognostic index is valid and hence general prognosis is rather similar with other breast cancer of same stage, except that more aggressive treatment is required. Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of relapse is much higher for the first 3—5 years, but drops sharply and substantially below that of hormone-positive breast cancers afterwards. This relapse pattern has been recognized for all types of triple-negative cancers for which sufficient data exist, although the absolute relapse and survival rates differ across subtypes. One known cause of triple negative breast cancer is germline mutations.
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8 Questions to Ask Your Doctor If You’re Diagnosed With Triple Negative Breast Cancer
Triple negative breast cancer | Cancer Research UK
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Determining risk of recurrence in triple-negative breast cancer
Because the cancer cells lack these proteins, treatment options for triple-negative breast cancer are limited. Hormone therapy and drugs that target HER2 are not helpful, so chemotherapy is the main systemic treatment option. And although, TNBC tends to respond well to initial chemotherapy, it tends to come back recur more frequently than other breast cancers. If the early-stage TNBC tumor is small enough for surgery then breast-conserving surgery or a mastectomy with a check of the lymph nodes may be done.
The cells test "negative" on all 3 tests. These cancers tend to be more common in women younger than age 40, who are African-American, or who have a BRCA1 mutation. Triple-negative breast cancer differs from other types of invasive breast cancer in that they grow and spread faster, have limited treatment options, and a worse prognosis outcome. Once a breast cancer diagnosis has been made using imaging tests and a biopsy , the cancer cells will be checked for certain features. If the cells do not have estrogen or progesterone receptors, and also do not make too much of the HER2 protein, the cancer is considered to be triple-negative breast cancer.